See the list of featured NIAID clinical trials below or view the complete list of NIAID studies recruiting participants on ClinicalTrials.gov.
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18 Results
A Deep Longitudinal Analysis of Next Generation Influenza Vaccines in Older Adults
This is a prospective, single-arm study designed to understand the mechanisms that lead to a loss of response to influenza vaccine in older adults.
A Study to Evaluate the Safety and Immunogenicity of Two Doses of DCVC H1 HA mRNA-LNP in Healthy Adults
The primary objective of this study is to assess the safety of two doses of DCVC H1 HA mRNA vaccine administered intramuscularly in healthy adults (18-49 yrs) at dosage levels of 10 mcg, 25 mcg, and 50 mcg.
Bone Marrow and Peripheral Blood Immune Responses Study
The purpose of this study is to evaluate the immune response of the killed flu vaccine in healthy subjects.
Characterization of Humoral and Cellular Immune Responses Elicited by Influenza Vaccination in Healthy Adults
In this study, the investigators will measure influenza virus cellular and humoral immune responses in individuals of different birth years before and after influenza vaccination.
COVID-19 Coagulopathy Extension Study
The study design will be a longitudinal cohort study, which will allow for the determination of the time course of enhanced thrombin generation potential in relation to clinical outcomes and changes in markers of cellular activation in serial samples obtained from COVID-19 patients for up to 3 years after infection with SARS-CoV-2
Dissecting Human Immune Responses to Infection with Influenza or SARS-CoV-2
The purpose of this study is to evaluate the virus-specific immune response in people who are symptomatic with confirmed influenza or COVID-19.
Experimental Influenza Vaccine (FluMos-v2) Study
This is a study of an experimental influenza (flu) vaccine called the FluMos-v2 vaccine. This vaccine study will provide more information about flu vaccines that may one day lead to a universal flu vaccine. A universal flu vaccine would be effective against all influenza strains.
Flu Infection at UPHS
The objective of this study is to evaluate if the influenza infection will elicit mostly memory immune responses rather than de novo immune responses to infection.
High vs. Standard Dose Influenza Vaccine in Pediatric Solid Organ Transplant (SOT) Recipients
This is a phase II, multi-center, double-blind, randomized controlled immunogenicity and safety trial comparing two doses of high-dose-quadrivalent inactivated influenza vaccine (HD-QIV) or two doses of standard-dose-quadrivalent inactivated influenza vaccine (SD-QIV) in pediatric solid organ transplant (SOT) recipients.
Influenza IMPRINT Cohort: Defining the Impact of Initial Influenza Exposure on Immunity in Infants
The primary aim of this study is to define the immune responses to the infant's initial influenza exposure (vaccine or infection) and how that affects the immune response to subsequent influenza exposures.
Low Pathogenicity Avian H10N7 Influenza Virus in a Healthy Human Challenge Model (20-I-0160)
Researchers at the National Institutes of Health (NIH) are recruiting for an inpatient flu study to learn more about flu. If you are healthy and interested in helping us fight the flu, we need you for this research study!
This is a dose-finding and pathogenicity study following human challenge with a low pathogenicity avian influenza A H10N7. Participants will be inoculated with 1 dose of challenge virus during the study and then followed for a minimum of 9 weeks after inoculation. Progressively increasing doses will be used according to a specific plan until either the maximum dose is reached or at least 60% of participants develop mild to moderate influenza disease (MMID).
Natural History of Systemic and Nasal Mucosal Immunity to Influenza and SARS-CoV-2 in Adults After Vaccination
NIAID is recruiting NIH staff members to help researchers make discoveries about COVID-19 and influenza including learning about long-term immunity in people who receive COVID-19 and/or flu vaccines.
Observational Digital Biomarker Discovery in Respiratory Virus Challenge Studies
The purpose of this study is to use digital devices to collect data from participants in challenge studies that could indicate subtle changes in health during an infection that might otherwise go unnoticed.
Respiratory Virus Sampling and Repository
The purpose of this study is to obtain samples from people with respiratory viruses to learn more about respiratory virus infections and the immune responses against them.
Screening Healthy Volunteers for Influenza Challenge Studies
If you are healthy, have some time, and have an interest in helping researchers make discoveries about influenza (the flu), we need you for a screening study. The screening is used to determine eligibility for future studies that will help researchers learn more about the development and course of the flu virus.
Systems Investigation of Vaccine Responses in Aging and Frailty
This study will compare the immune response signatures (including immunologic, transcriptomic and metabolomic) of the two influenza vaccines approved for use in adults age 65 and over (Fluad and Fluzone High-Dose).
Understanding Immunity to the Flu Vaccine in COVID-19 Patients
The purpose of this study is to measure immunity to the flu vaccine over time in patients who had COVID-19. Adults who have been diagnosed with COVID-19 as well as controls without COVID-19 will be invited to participate in this study.