Division of Intramural Research

Steven M. Holland, M.D.

Steven M. Holland, M.D.
Director, Division of Intramural Research

Credit: NIH

The Division of Intramural Research (DIR) is a component of NIAID, one of the largest Institutes of the National Institutes of Health (NIH). For more than 65 years, DIR has been at the forefront of research on immunologic, allergic, and infectious diseases. Our purpose is to make scientific discoveries that promote the development of new vaccines, diagnostics, and therapeutics that improve human health. DIR Research goals are to expand knowledge of normal immune system components and functions, define mechanisms responsible for abnormal immune function (immunodeficiency, allergy, and autoimmunity), understand the biology of infectious agents (viruses, bacteria, fungi, and parasites) and the host response to infection, and develop strategies to prevent and treat immunologic, allergic, and infectious diseases.

DIR scientists study all aspects of infectious diseases, including the causative agents and their vectors, and pathogenesis in human and animal hosts. Clinical research also is integral to the DIR mission, enabling key lab discoveries to be rapidly translated into methods to prevent, diagnose, or treat disease. DIR researchers conduct more than 180 clinical trials at the NIH Clinical Center on the Bethesda, Maryland, campus and at collaborating U.S. and international sites

View all Division of Intramural Research laboratories

Read DIR Opportunities: Research and Training Programs for 2019 – 2020


NIAID partners with scientific leaders to better understand the diseases and move forward toward better prevention, diagnosis and treatment.

See NIAID-supported networks related to DIR research

COVID-19 Research in NIAID Labs

When COVID-19 was identified in early 2020, NIAID intramural laboratory scientists mobilized quickly to study the virus.  See a list of intramural investigators researching COVID-19.

Immune Response to COVID-19
NIAID researchers are spearheading a large, international collaboration to investigate the innate and adaptive immune responses during acute COVID-19 infection and convalescence. The overall goal is to identify immunological and virological correlates and predictors of clinical outcomes. Read about the projects involved in the immune response to COVID-19.

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