See the list of featured NIAID clinical trials below or view the complete list of NIAID studies recruiting participants on ClinicalTrials.gov.
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Tratamiento ambulatorio con inmunoglobulina anticoronavirus (Outpatient Treatment with Anti-Coronavirus Immunoglobulin, OTAC)
Un estudio de investigación que prueba un tratamiento contra el COVID-19 en fase de investigación conocido como concentrado de inmunoglobulinas de administración intravenosa hiperinmunitarias (hIVIG) anticoronaviral.
Trial of an Inactivated Chikungunya Virus Vaccine
The primary objective of this trial is to evaluate dosages and assess the safety and reactogenicity of the HydroVax-005 CHIKV vaccine.
TrialNet Pathway to Prevention of Type 1 Diabetes
The goal of this study is to enhance understanding of the demographic, immunologic, and metabolic characteristics of individuals at risk for developing type 1 diabetes.
TRITON Study
We are studying a condition called paradoxical reaction that some people get when they take treatment for tuberculosis (TB). Most people with TB feel better after starting treatment. But for some people, the opposite happens. They may feel better at first, but then suddenly get worse. This opposite effect is a paradoxical reaction. We do not understand how this reaction happens. It can be hard to tell whether worsening symptoms are caused by a paradoxical reaction or something else, such as if the treatment just is not working.
Tyrosine Kinase Inhibition to Treat Myeloid Hypereosinophilic Syndrome
The purpose of this study is to evaluate the safety and efficacy of the tyrosine kinase inhibitor, imatinib mesylate (Gleevec ) in reducing peripheral blood eosinophilia in patients with the myeloid form of hypereosinophilic syndrome (HES).
Understanding Allergies and Sensitizations in Healthy and Allergic Individuals
The purpose of this study is to strengthen our ability to accurately diagnose allergies and understand cellular, humoral, genetic components and physiological changes in allergic disease.
Understanding Immunity to the Flu Vaccine in COVID-19 Patients
The purpose of this study is to measure immunity to the flu vaccine over time in patients who had COVID-19. Adults who have been diagnosed with COVID-19 as well as controls without COVID-19 will be invited to participate in this study.
Understanding Poor Vaccine Responses to Hepatitis B Vaccination
This study aims to study the immunology of hepatitis B vaccine responses by comparing traditional HBV vaccine, which is associated with nonresponses in some patients, to CpG-adjuvanted HBV vaccine, which is associated with far fewer rates of nonresponses.
Use of G-CSF to Obtain Blood Cell Precursors
This protocol is designed to study the techniques needed to develop gene therapy or other treatments for certain inherited immune system diseases.
Vaginal Microbiome Seeding and Health Outcomes in Cesarean-delivered Neonates.
The objective of this study is to evaluate if the restoration of the vaginal microbiota to the infant at birth will restore the infant microbiome and decrease the risk of obesity and other immune-mediated diseases linked with Cesarean section (CS).
Very Early Intensive Treatment of Infants Living With HIV to Achieve HIV Remission
The study will explore the effects of early intensive antiretroviral therapy (ART) with or without a broadly neutralizing antibody (bNAb) on achieving HIV remission (HIV RNA below the limit of detection of the assay) among infants living with HIV.
VIBRANT: VIB4920 for Active Lupus Nephritis
This is a multi-center double-blind placebo controlled clinical trial evaluating the efficacy of VIB4920 combined with mycophenolate mofetil (MMF) and prednisone in achieving a renal response in participants with active lupus nephritis (LN).
Viral Infections in Healthy and Immunocompromised Hosts
The objective of this study is to collect samples and data from individuals who have been exposed to or have contracted viral infections.
Viral Infections in Non-Immunocompromised Patients
This study seeks patients who are thought to have normal immune systems, but who have been diagnosed with a viral infection that is unusually severe, prolonged, or persistent. This study will evaluate the participants’ immune systems to determine why the infection developed.
Viral Load in Blood and Lymph Tissues of HIV-Infected Individuals
The goal of this study is to investigate if the seeding of lymph nodes by HIV early in the course of HIV infection and the persistent production of virus in lymph nodes throughout the course of infection are major factors in the pathogenesis of HIV in virtually all infected individuals.
Viral Mucosal Reprogramming
The purpose of this study is to evaluate the effects of RG-RV16 inoculation on airway mucosal gene expression and airway remodeling in 25 healthy controls (HC), in 25 allergic rhinitis subjects (AR) with cat dander allergy, and in 25 allergic asthmatic subjects (AA) with cat dander allergy.
VRC 900 Evaluation of Tissue-Specific Immune Responses in Adults 18 Years of Age and Older
Researchers need to collect specimens and images from individuals who have recently had a vaccination or recovered from an infection. These specimens and images are used to study different diseases and immune responses, and can be used to investigate ways to prevent or treat different medical conditions.
Wells and Enteric Disease Transmission
The purpose of this study is to test if household treatment of private well water by ultraviolet light (UV) vs. sham (inactive UV device) decreases the incidence of gastrointestinal illnesses (GI) in children under 5. We will also examine the presence of viral, bacterial, and protozoan pathogens in stool and well water from participants.
WINGS Healthy Volunteer Study
The purpose of the study is to test HIV vaccines to see if they are safe. It is not possible to get HIV through participating in the study. Vaccines are used to create resistance to a disease, or to prevent infection. The study vaccines will use a live adenovirus, the type of virus that typically causes cold symptoms. We hope that this adenovirus will help to stimulate an immune response against HIV.