Yes, many NOFOs list 3 years of due dates when published. A lot can change in just 1 year’s time, so you should make a habit of checking a NOFO within 30 days of your due date to ensure you are meeting the latest requirements before submitting.
Pay special attention to any “Related Notices” listed in Part I. Overview Information of the NOFO. For example, NIAID adjusted the application budget for NIAID Research Education Program Advancing the Careers of a Diverse Research Workforce (R25, Clinical Trial Not Allowed) after the NOFO was published, and we issued a related notice saying so.
If you submit more than 30 days prior to the due date, the same advice applies. Revisit the NOFO and check to ensure your submitted application meets all current requirements. If it doesn’t, you should officially Withdraw Your Application, make the needed adjustments, and submit again before the deadline.