“Can I submit the same research project as an R01 application and an R21 application simultaneously?”

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No, applicants are not allowed to have duplicative or highly overlapping applications under review at the same time, as explained at Evaluation of Unallowable Resubmission and Overlapping Applications. As a rule of thumb, you need to wait until you receive a summary statement for the first application before you submit another application with highly overlapping scientific aims.

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