NIAID aims to support research on the discovery and characterization of inborn errors of immunity (IEIs), also referred to as primary immunodeficiencies, through Notice of Special Interest (NOSI): Inborn Errors of Immunity/Primary Immunodeficiencies.
The goal of the NOSI is to encourage research to understand causes and mechanisms of IEIs, enable early detection and molecular diagnosis, and support the development of strategies to treat and eventually cure these disorders.
Advances in whole genome sequencing and similar state of the art, high throughput methods have led to accelerated discovery of new genes and molecular pathways responsible for aberrant or sub-optimal immune responses, which, in turn, can lead to increased infections or other diseases related to the immune system. Identification of molecules and pathways associated with IEIs should inform development of novel diagnostic methods and enable rational design of personalized therapies based on patient-specific diagnoses.
Review the NOSI for additional research areas of specific interest. Interested applicants may contact NIAID through the email address listed at the end of this article to determine responsiveness of applications on research topics not listed.
Application and Submission Information
This notice applies to NIH Standard Due Dates on or after June 5, 2024, and subsequent receipt dates through March 16, 2027.
Submit applications for this initiative using one of the following notices of funding opportunities (NOFOs) or any subsequent reissues through the expiration date of this notice.
- NIH Research Project Grant (Parent R01, Clinical Trial Not Allowed)
- NIH Exploratory/Developmental Research Grant Program (Parent R21, Clinical Trial Not Allowed)
- NIH Small Research Grant Program (Parent R03, Clinical Trial Not Allowed)
Budgets, project periods, and receipt dates for applications submitted under this NOSI follow standard requirements for R01, R21, and R03 NOFOs listed above. Therefore, refer to your chosen NOFO for those application requirements.
All instructions in the SF 424 (R&R) Application Guide and the NOFO used for submission must be followed, with the following addition:
Applicants must include “NOT-AI-24-024” in the Agency Routing Identifier field (box 4B) of the SF 424 R&R form. Applications without this information in box 4B may not be directed to the correct program officer.
Contact Information
If you have any questions about the NOSI, reach out to Dr. Maggie A. Morris Fears at maggie.morrisfears@nih.gov or 301-761-5444.