Chief, Cellular Immunology Section
Provides direct clinical care to patients at NIH Clinical Center
Education:
M.D., 1986, Tufts University, Medford, MA
B.A., 1981, Johns Hopkins University, Baltimore, MD
Biography
Dr. Seder received his B.A. in Natural Science at Johns Hopkins University in 1981 and his M.D. at Tufts University in 1986 and completed his residency in internal medicine at New York Hospital-Cornell Medical Center. Dr. Seder did his postdoctoral training at NIAID with Dr. William Paul. He is currently Chief of the Cellular Immunology Section in the Vaccine Research Center in the NIAID, NIH. Dr. Seder's laboratory has focused on the cellular and molecular mechanisms by which vaccines and adjuvants mediate protective immunity in mouse, and non-human primate models of HIV, Malaria, Tuberculosis and cancer. His work has demonstrated the importance of the quality of T cell responses in mediating protection against various infections and the importance of the route of vaccination in generating tissue resident T cells for protection against malaria and TB. Dr. Seder has translated his scientific discoveries and led the first in human clinical studies using intravenous vaccination to generate protective immunity with an attenuated malaria vaccine and recently showed that a monoclonal antibody he discovered can prevent malaria infection against intense seasonal transmission in African adults. Over the two years, Dr. Seder has helped lead the pre-clinical development of the Moderna mRNA vaccine against COVID. This provided pre-clinical data for demonstrating safety and efficacy of the Moderna vaccine in animals prior to the initiation of the pivotal Phase 3 study in humans and more recently provided the scientific basis for boosting humans with mRNA against variants.