Chief, Immune Deficiency Genetics Section
Deputy Chief, Laboratory of Clinical Immunology and Microbiology
NIH Distinguished Investigator
Specialty(s): Allergy and Immunology, Pediatrics Provides direct clinical care to patients at NIH Clinical Center
Education:
M.D., University of Pavia, Italy
Biography
Luigi D. Notarangelo received his M.D. from the University of Pavia, Italy. After completing training in pediatrics, subspecialty training in allergy/immunology, and human genetics at the University of Pavia and a postdoctoral internship with David Nelson, M.D., at the Metabolism Branch, National Cancer Institute, he was appointed associate professor and subsequently full professor of pediatrics at the University of Brescia, Italy, where he chaired the department of pediatrics between 2000 and 2006. In November 2006, he joined the division of immunology at Boston Children’s Hospital, Harvard Medical School, as professor of pediatrics. In October 2016, he joined the National Institute of Allergy and Infectious Diseases. In 2017, he was named Chief of the Laboratory of Clinical Immunology and Microbiology (LCIM) at NIAID, and in 2025, he became Deputy Chief of LCIM.
Dr. Notarangelo is a leader in the study of the molecular and cellular mechanisms of human primary immune deficiencies and in the treatment of these disorders. He has served as president of the European Society for Immune Deficiencies and of the Clinical Immunology Society. He has received numerous national and international awards. In 2019, he was elected to the National Academy of Medicine.