Chief, Signaling Systems Section
Specialty(s): Allergy and Immunology, Infectious Disease
Education:
Ph.D., Imperial College, University of London
Biography
Dr. Fraser received his B.S. in biochemistry from Heriot-Watt University, Edinburgh, Scotland, and his Ph.D. in biochemistry from Imperial College, University of London. He was a Welcome Trust International postdoctoral fellow at the Vollum Institute in Portland, Oregon. He joined the Alliance for Cellular Signaling (AfCS) research consortium in 2000 as lead scientist of the molecular biology group at the California Institute of Technology and became co-director of the AfCS Molecular Biology Laboratory in 2005. He joined NIAID in 2008 as leader of the PSIIM Molecular and Cell Biology Team and became chief of the Signaling Systems Unit within the Laboratory of Systems Biology (LSB) in 2011. In 2017 he was appointed as a tenured senior investigator and chief of the Signaling Systems Section.
His research has focused on the mechanistic basis of cellular signaling, both in G protein signaling networks and more recently in toll-like receptor-mediated regulation of inflammatory responses. He applies systems biology approaches to decipher how mammalian cells, particularly macrophages, integrate infectious and inflammatory stimuli in a complex environment to ensure an appropriate host immune response. This is vital to understanding how a breakdown in information processing through macrophage cell-surface receptors and their linked signal transduction pathways can lead to human inflammatory disease states.
Special Interest Groups
- Immunology
- Systems biology
- Inflammatory Disease
- Proteomics
- Cytokine