Goodenow Research Group

Molecular HIV Host Interactions Section (MHHIS) conducts research to study interactions between HIV-1 and human host, in particular children and young adults, to address the effect of recreational substance use on gene expression and biological pathways; immune perturbation in HIV-exposed but uninfected (HEU) infants; development and maturation of immunoglobulin repertoires, and response to vaccines in early human life; and HIV-1 cell tropism, latency, reservoir, reactivation, and evolution of the HIV-1 over the course of infection with/without ART.

Maureen M. Goodenow, Ph.D.

Chief, Molecular HIV Host Interactions Section
Director, NIH Office of AIDS Research

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Education:

Ph.D., Albert Einstein College of Medicine, The Bronx, NY

Dr. Goodenow received her undergraduate degree in biology from Fordham University and her Ph.D. in molecular genetics from the Albert Einstein College of Medicine. Following a postdoctoral fellowship in molecular oncology at the Sloan Kettering Institute she began her study of HIV. Dr. Goodenow has published more than 100 articles and book chapters, in addition to serving as a reviewer for more than 10 journals.

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Li Yin, M.D., D.C.H, Ph.D.

Staff Scientist

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Education:

M.D., Doctor of Medicine

D.C.H., Diploma in Child Health

Ph.D., Doctor of Philosophy

Languages Spoken: Mandarin

Dr. Li Yin’s research interests are: (1) Influence of recreational substance use on gene expression and biological pathways in YWH on ART; (2) Study of immune perturbation in HEU children in comparison to HUU children; (3) Development and maturation of immunoglobulin repertoires, and response to vaccines in early human life.

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Kai-Fen Chang, M.S.

Biologist

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Languages Spoken: Mandarin, Taiwanese

Kai-Fen studies the influence of recreational substance use on gene expression and biological pathways in YWH on ART; development and maturation of immunoglobulin, and response to vaccines in early human life; immune perturbation in HEU children in comparison to HUU children.

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Isaac Daniel Raplee, Ph.D.

Biologist (Bioinformatician)

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Education:

Ph.D., Biomedical Science – Molecular Medicine, Morsani College of Medicine, University of South Florida

Isaac is a transcriptomics specialist with expertise in analyzing noncoding-RNA, miRNA, mRNA, and other RNA species’ expression in convoluted experimental designs. He has special interest in exogenous and endogenous retroviruses and host interactions.

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Samiksha A. Borkar, M.S.

Research Associate

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Education:

M.S., 2016, Ph.D., 2023, George Mason University, Fairfax, VA

Languages Spoken: Marathi, Hindi

Samiksha is working on studying the influence of substance use mainly recreational marijuana and tobacco on HIV-modulated gene expression. She is also interested in investigating the role the HIV-Host interaction in HIV pathogenesis using multi-omics data.

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Upasana Nepal, B.S.

Lab Technician

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Education:

B.S., 2019, The University of Texas at Austin

Languages Spoken: Nepali, Hindi

Upasana is working with various lab members to study: (1) Influence of recreational substance use on gene expression and biological pathways in YWH on ART; (2) Immune perturbation in HEU children in comparison to HUU children.

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Jerry Shen

Student Trainee

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Languages Spoken: Mandarin

Jerry is a motivated sophomore undergraduate student at the University of Maryland. He is working with lab members to study (1) the effectiveness of computational cell deconvolution methods on PBMCs in individuals with HIV, and (2) the influence of recreational marijuana and tobacco use on HIV-modulated gene expression.

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