Yes. As with any Multiple Principal Investigators application, you should justify your rationale for the approach, e.g., how taking a multidisciplinary approach will accomplish more and have a higher impact than a single PI approach could.
Take note that your Leadership Plan should outline the governance and organizational structure of the research project, including communication plans and procedures for resolving conflicts. Refer to NIH’s Questions Specific to Applications with PIs from Multiple Institutions for instruction on arranging consortium budgets.