NIAID will support administrative supplement awards to promote the development of pediatric chemical research models and medical countermeasures (MCM) discovery under the Chemical Countermeasures Research Program (CCRP). There is currently an unmet need in understanding the natural history, pathophysiology, and treatment of critical illness in infants, children, adolescents, and young adults after exposure to highly toxic, Department of Homeland Security-designated chemicals of concern (CoCs).
The administrative supplements will fund pilot preclinical projects by CCRP-supported researchers that focus on 1) basic research to elucidate mechanistic differences in susceptibility to CoCs between pediatric and adult populations or 2) applied research towards the discovery and early development of pediatric-safe MCMs.
Research Objectives
Through Notice of Special Interest (NOSI): Chemical Countermeasures Research Program (CCRP) Administrative Supplements to Promote the Development of Pediatric Research Models of Chemical Injury and Medical Countermeasures Discovery, current CCRP award recipients are eligible to receive supplemental funds to incorporate pediatric relevant chemical MCM research efforts, within the scope of the approved award, that were unforeseen when the new or renewal application or grant progress report for noncompeting continuation support was submitted.
Examples of relevant research areas include developing new pediatric research models and MCM efficacy studies. Applicants must propose research that, if successful, would contribute to a greater understanding of the health, well-being, or medical treatment of the pediatric population during and after a public health emergency involving CoCs.
CCRP will prioritize recipients with research project grants (e.g., R01, R21, R34) over those working under cooperative agreements (e.g., U01, UG3/UH3, U54, U2C).
Application and Submission Information
Submit an application for this initiative using the following notice of funding opportunity (NOFO) or its subsequent reissued equivalent.
Follow all instructions in the SF 424 (R&R) Application Guide and the parent administrative supplements NOFO, with the following additions:
- Budgets are limited to lesser of the amount of the current award or $99,999 in direct costs, and must be spent within the currently approved project period.
- Applications are due on May 6, 2024; March 17, 2025; or March 16, 2026, by 5:00 p.m. local time of the applicant organization.
- You must include “NOT-AI-24-022” in the Agency Routing Identifier field (box 4B) of the SF 424 R&R form. Applications without this information in box 4B will not be considered for this initiative.
We encourage you to notify the program official listed on your Notice of Award that you are submitting a request in response to this NOSI to facilitate efficient processing of your request.
Refer to the NOSI, linked above, for additional application instructions.