As part of the notice of funding opportunity (NOFO) U.S.-South Africa Program for Collaborative Biomedical Research—Phase 3 (HIV/AIDS) (R01, Clinical Trial Optional), NIAID, along with other NIH institutes and centers (ICs) and the South African Medical Research Council, will support the next phase of a collaborative program between U.S. and South African scientists carrying out HIV/AIDS research.
For Phase 3, NIAID is calling for applications to help foster, stimulate, and expand research on HIV/AIDS, HIV/AIDS comorbidities and co-infections, HIV/AIDS-associated implementation science, and HIV/AIDS-associated data science. The goal of this NOFO is to engage collaborative teams of U.S. and South African scientists working on these areas of research.
Research Objectives
As part of this NOFO, we encourage HIV-related research that’s in accordance with NIH’s overarching HIV research priorities as well as the NIH HIV/AIDS Research Priorities and Guidelines for Determining HIV/AIDS Funding.
Our specific research areas of interest are as follows:
- Reduce incidence of HIV (prevention)
- Develop next-generation HIV therapies (treatment and care continuum)
- Research toward HIV cure
- Address HIV-associated comorbidities, co-infections, and complications
- Cancer
- Behavior, mental health, substance use, and HIV risk
- Implementation science/data science
Refer to the NOFO for possible projects within each research area of interest.
Note that we will consider applications proposing the following topics to be nonresponsive and not review them:
- Projects proposing Phase III or Phase IV Clinical Trials.
- Research using Select Agents.
- Applications without the required collaborative partnership (at least one South African program director/principal investigator (PD/PI) from an eligible institution from South Africa and at least one collaborator from a U.S. institution/organization).
Who Can Apply
Eligible National Research Foundation (NRF) South African Institutions, i.e., recognized South African public higher education or research institutions, can apply. (Refer to the NOFO for further details on eligible NRF South African institutions. Note that the South African Institution must submit the application, with the South African PI serving as the contact PI. The U.S. partner can serve as a PI on a multi-PI application or as a non-PI collaborator.)
Application and Budget Information
Applicant organizations may submit more than one application, provided that each application is scientifically distinct. Applicants will be required to include a data management and sharing plan that adheres to the NIH Grants Policy Statement.
Issuing IC and partner components intend to fund 8 to 10 awards. Application budgets are not expected to exceed $400,000 in direct costs per year and must reflect the actual needs of the proposed project. While the maximum project period is 5 years, the scope of the proposed project should determine the project period.
The application deadline is March 12, 2025.
For more information, refer to Questions and Answers for U.S.-South Africa Program for Collaborative Biomedical Research—Phase 3 (HIV/AIDS). You can also contact Brian Remortel with NIAID-specific questions at remortelbg@niaid.nih.gov or 240-292-4816. Refer to the NOFO for contacts at other ICs.