Atopic dermatitis (AD), also called eczema, makes skin dry, red, and itchy. People with AD are more likely to get a food allergy than people without AD. But some food allergy tests are not always accurate in people with AD. Researchers want to study if people with AD and high total IgE levels are truly allergic to milk and/or peanuts with the aim of improving the ways doctors test for food allergy in people with AD.
What Does the Study Involve?
In this study, participants aged 3-21 years (n = 175) with elevated total serum IgE levels and a history of AD will receive a comprehensive allergy evaluation including food allergy testing, a plan and medications to treat their AD, and a nutritional assessment and counseling sessions with a dietitian. Additionally, participants will undergo open feedings and/or double-blind, placebo-controlled food challenges (DBPCFCs) to peanuts and/or milk. The challenges will conclusively determine if the participant is truly allergic to milk and/or peanuts and whether they can safely reintroduce the food(s) into their diet or if they need to continue avoiding the food(s). The challenges are done in an inpatient unit at the NIH Clinical Center with staff who have expertise in performing food challenges.
Who Can Participate?
People ages 3-21 who have had AD and have a high total IgE level (an allergic antibody)
Where Is It Taking Place?
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Is There a Cost?
Participants will not be charged for any service offered, and medical insurance is not required.
Is Compensation Provided?
Participants will be compensated for their time and travel/accommodation expenses.
Number of Visits Required
2-3 visits
Steps To Participate
Contact us at 301-761-7565 or at niaidfars2@nih.gov
Sponsor
Thermo Fisher
Collaborators
Pamela A Guerrerio, M.D.
Visit ClinicalTrials.gov for details.
Contact Information
Contact us at 301-761-7565 or at niaidfars2@nih.gov