With tickborne diseases increasing in the United States and globally, combating this rising public health threat requires improved prevention strategies, diagnostics, and treatments. Each of these tools may target or depend on the human immune response to infection, and therefore understanding immune evasion by pathogens may be a critical factor in their design or utilization.
Through the Notice of Special Interest (NOSI): Understanding Immune Evasion in Tickborne Diseases, NIAID 1) invites applications on mechanisms of immune evasion among tickborne human pathogens, including translational interventions targeting those mechanisms for improved vaccines, therapeutics, and diagnostic tests, and 2) encourages applications in the field, including from researchers in other disciplines who may have new perspectives to bring to existing gaps.
Mechanisms—and corresponding interventions—that are applicable across strains and species are of particular interest. We encourage projects using new or established animal models and human clinical samples.
Application and Submission Information
Submit applications for this initiative using one of the following notices of funding opportunities (NOFOs) or any reissues of these opportunities through the expiration date of this notice. The first available due date is October 5, 2023.
- PA-20-185—NIH Research Project Grant (Parent R01, Clinical Trial Not Allowed)
- PA-20-200—NIH Small Research Grant Program (Parent R03, Clinical Trial Not Allowed)
- PA-20-195—NIH Exploratory/Developmental Research Grant Program (Parent R21, Clinical Trial Not Allowed)
For consideration under this NOSI, applicants must include “NOT-AI-23-053” (without quotation marks) in the Agency Routing Identifier field (box 4B) of the SF 424 R&R form. Applications without this information in box 4B will not be considered for this NOSI initiative.
Note that there is not a special emphasis panel or set-aside funds associated with this NOSI.
If you have questions, direct them to Dr. Nadine Bowden at nadine.bowden@nih.gov or 301-761-6973.