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Next-generation Genetic Tools Reveal New Aspects of Enterovirus Evolution

NIAID scientists developed tools to study evolution in enteroviruses—a virus group responsible for polio; hand, foot & mouth disease (HFMD); acute flaccid myelitis (AFM) & other diseases. Their findings may reveal pathways of viral evolution.

Scientists Discover Cause, Potential Treatment for Cases of Deadly Autoimmune Disorder

Discovery of a gene variant causing some cases of APECED, a rare inherited autoimmune disease, will enable earlier diagnosis & medical care that may prolong lives.

Gene Signature at Birth Predicts Sepsis in Newborns Before Signs Appear

A four-gene signature in newborns’ blood at birth predicts before symptom onset whether a baby will develop neonatal sepsis during the first week of life.

NIAID Scientists Detail First Structure of a Natural Mammalian Prion

Revealing the near-atomic structure of a chronic wasting disease prion from a deer should help scientists explain how CWD prions spread and become infectious.

Sequencing of Congo Mpox Reports Highlights New Transmission Patterns in Country

Laboratory analysis in the Republic of Congo showed mpox was affecting people in parts of the country where it has not been historically. The findings point to increases in human-to-human transmission across the border with the neighboring Democratic Republic of the Congo, where a large outbreak was declared a public health emergency of international concern.

NIAID Funds Cutting-Edge Genomics and Bioinformatics Programs

NIAID has announced six awards to continue the Genomics Centers for Infectious Diseases (GCIDs) and Bioinformatics Resource Centers (BRCs) for Infectious Diseases, both important data science networks offering critical resources for the scientific community.

A New Way to Measure and Predict Human Immune Health

The immune system senses and responds to changes in physiologic health, and a new tool called the immune health metric (IHM) can measure and even predict some of these changes, an NIAID study has found. If doctors could use the IHM to detect health problems long before symptoms appear, they could potentially act early to prevent disease, the investigators suggest.

Novel Study Model Reveals New Understanding of Fatal Familial Insomnia

Fatal familial insomnia (FFI) is a little-known yet horrific disease in which people die from lack of sleep. In a new study, NIAID scientists developed a cerebral organoid model to study the exact protein mutation that causes FFI.

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