Transition Program in Clinical Research (TPCR) Unit
Jessica E. Manning, M.D., M.Sc.
Assistant Clinical Investigator, Laboratory of Malaria and Vector Research
Science Attaché, U.S. Embassy Phnom Penh and NIAID ICER CAMBODIA
Contact: For contact information, search the NIH Enterprise Directory.
Specialty(s): Infectious Disease, Internal Medicine Provides direct clinical care to patients at NIH Clinical Center
Major Areas of Research
- Clinical and field epidemiology of dengue, Zika, malaria, and other diseases carried by mosquitos and other arthropod vectors in tropical, endemic areas
- Characterization of host immune response to mosquito saliva
- Application of metagenomic next generation sequencing in patients with fever to identify known and emerging pathogens and to better understand disease transmission
Program Description
The Transition Program in Clinical Research (TPCR), housed in laboratories in Rockville and at the NIAID International Center of Excellence in Research (ICER) Cambodia, integrates innovative ideas like vector-targeted immunological strategies and cutting-edge technologies like pathogen metagenomic sequencing into traditional epidemiological studies in Southeast Asia. Together, the team aims to apply and translate our findings to inform public health and disease prevention measures like vector control as well as vaccine development and implementation.
Biography
Education
M.D., Emory University School of Medicine
M.Sc., Harvard School of Public Health
Dr. Manning earned her medical degree from Emory University School of Medicine and her Master of Science in Epidemiology from Harvard School of Public Health. She completed the Doris and Howard Hiatt Residency in Global Health Equity and Internal Medicine at Brigham and Women’s Hospital while a clinical fellow at Harvard Medical School. From 2008 to 2015, she lived and worked in Africa and Southeast Asia as part of her medical and scientific training in international clinical research. In 2015, she became an Infectious Diseases fellow under the National Institute of Allergy and Infectious Diseases at the NIH Clinical Center in Bethesda, Maryland. She moved to NIAID’s Laboratory of Malaria and Vector Research in Cambodia in 2017 to expand the clinical research program and serve as NIAID Science Attaché at the U.S. Embassy Phnom Penh. In 2019, she was awarded a place in the NIAID Transition Program in Clinical Research to continue her work in vector-borne disease epidemiology and host immune responses to vector saliva.
She is currently an assistant clinical investigator residing full-time in Cambodia where she leads NIAID's collaborative field sites and laboratories, known as the International Center of Excellence in Research (ICER Cambodia), devoted to clinical and translational research of vector-borne diseases, like dengue and multi-drug resistant malaria, as well as emerging pathogens.
Clinical Studies
- Characterization of Skin Immunity to Aedes Aegypti Saliva in Dengue-endemic Participants in Cambodia: NCT04350905
- Febrile Disease Landscape in Cambodia via Metagenomic Pathogen Sequencing: NCT04034264
- Investigating Vector-Borne Determinants of Aedes Transmitted Arboviral Infections in Cambodia: An Observational Longitudinal Cohort Study in Children: NCT03534245
- Sylvatic Transmission and Reservoir Potential of Zika, Dengue, and Chikungunya Viruses of Co-located Humans and Long-tailed Macaques in Thailand and Cambodia: NCT04434846
Selected Publications
Bohl JA, Lay S, Chea S, Ahyong V, Parker DM, Gallagher S, Fintzi J, Man S, Ponce A, Sreng S, Kong D, Oliveira F, Kalantar K, Tan M, Fahsbender L, Sheu J, Neff N, Detweiler AM, Yek C, Ly S, Sath R, Huch C, Kry H, Leang R, Huy R, Lon C, Tato CM, DeRisi JL, Manning JE. Discovering disease-causing pathogens in resource-scarce Southeast Asia using a global metagenomic pathogen monitoring system. Proc Natl Acad Sci U S A. 2022 Mar 15;119(11):e2115285119.
Christofferson RC, Parker DM, Overgaard HJ, Hii J, Devine G, Wilcox BA, Nam VS, Abubakar S, Boyer S, Boonnak K, Whitehead SS, Huy R, Rithea L, Sochantha T, Wellems TE, Valenzuela JG, Manning JE. Current vector research challenges in the greater Mekong subregion for dengue, Malaria, and Other Vector-Borne Diseases: A report from a multisectoral workshop March 2019. PLoS Negl Trop Dis. 2020 Jul 30;14(7):e0008302.
Manning JE, Oliveira F, Coutinho-Abreu IV, Herbert S, Meneses C, Kamhawi S, Baus HA, Han A, Czajkowski L, Rosas LA, Cervantes-Medina A, Athota R, Reed S, Mateja A, Hunsberger S, James E, Pleguezuelos O, Stoloff G, Valenzuela JG, Memoli MJ. Safety and immunogenicity of a mosquito saliva peptide-based vaccine: a randomised, placebo-controlled, double-blind, phase 1 trial. Lancet. 2020 Jun 27;395(10242):1998-2007.
Manning JE, Oliveira F, Parker DM, Amaratunga C, Kong D, Man S, Sreng S, Lay S, Nang K, Kimsan S, Sokha L, Kamhawi S, Fay MP, Suon S, Ruhl P, Ackerman H, Huy R, Wellems TE, Valenzuela JG, Leang R. The PAGODAS protocol: pediatric assessment group of dengue and Aedes saliva protocol to investigate vector-borne determinants of Aedes-transmitted arboviral infections in Cambodia. Parasit Vectors. 2018 Dec 20;11(1):664.
Manning J, Lon C, Spring M, Wojnarski M, Somethy S, Chann S, Gosi P, Soveasna K, Sriwichai S, Kuntawunginn W, Fukuda MM, Smith PL, Rekol H, Sinoun M, So M, Lin J, Satharath P, Saunders D. Cluster-randomized trial of monthly malaria prophylaxis versus focused screening and treatment: a study protocol to define malaria elimination strategies in Cambodia. Trials. 2018 Oct 16;19(1):558.
Manning JE, Morens DM, Kamhawi S, Valenzuela JG, Memoli M. Mosquito Saliva: The Hope for a Universal Arbovirus Vaccine? J Infect Dis. 2018 Jun 5;218(1):7-15.
Research Group
In Maryland labs and the NIAID ICER Cambodia, the unit integrates innovative ideas like vector-targeted immunological strategies and cutting-edge technologies like pathogen metagenomic sequencing into traditional epidemiological studies in Southeast Asia. The team aims to inform public health and disease prevention measures like vector control as well as vaccine development and implementation.