Experimental Influenza Vaccine (FluMos-v2) Study

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This is a study of an experimental influenza (flu) vaccine called the FluMos-v2 vaccine. This vaccine study will provide more information about flu vaccines that may one day lead to a universal flu vaccine. A universal flu vaccine would be effective against all influenza strains.

The primary purpose of this study is to see if the experimental influenza (flu) vaccine called the FluMos-v2 vaccine is safe, and to determine how your body responds to it.

What Does the Study Involve?

If you agree to participate in the study, you will have 2 in-person vaccination visits at the clinic about 4 months apart. Each visit will take about 6 hours. You will also have 2 phone call follow-ups and 9 follow-up clinic visits over 40 weeks. Most follow-up clinic visits will take about 1 to 2 hours.

You will have a total of 11 clinic visits over 40 weeks (10 months). During this time, you must not get the seasonal (licensed) flu vaccine. It is important that you do not get a flu vaccine from anywhere else, such as your doctor or a local pharmacy, because it will confuse the results of this study.

Who Can Participate?

You may be eligible if you

• Are healthy and between the ages of 18 and 50
• Have a Body Mass Index (BMI) less than or equal to 35 (calculate your BMI)
• Are not pregnant, breastfeeding, or planning to become pregnant while on study
• Have received at least one licensed influenza (flu) vaccine from 2018 through 2022-2023
• Have not received the 2023-2024 seasonal flu vaccine

Where Is It Taking Place?

This study is being conducted at the NIH Clinical Center located on the Metro Red Line Medical Center stop in Bethesda, Maryland.

Is There a Cost?

There are no costs to you for participating in this study. All visits and procedures at the NIH Clinical Center are done for research purposes under a protocol plan. 

Is Compensation Provided?

You will be compensated for your time and inconvenience by the NIH Clinical Research Volunteer Program.  The approximate total compensation is up to $3,050 depending on the number of visits and procedures completed. 

If you are unable to finish the study, you will receive compensation only for the parts you completed.

How Many Visits are Required?

The study has 9 follow-up clinic visits and 2 in-person vaccination visits for a total of 11 clinic visits over 40 weeks (10 months).

What Are The Steps To Participate?

Schedule a telephone prescreen to see if you are initially eligible for this study:

1. Call: 1-866-833-5433 or  (TTY: 1-866-411-1010), or
2. Email: vaccines@nih.gov 

More Information

Visit: https//www.niaid.nih.gov/about/vrc

Visit ClinicalTrials.gov for details.