CMCRC Radiobiology Textbook

A primary task of the Centers for Medical Countermeasures Against Radiation Consortium (CMCRC) is education. This is a Radiobiology Methods “virtual textbook” that aims to provide the general scientific and educational community with a clear overview of radiation biology and dosimetry and inform readers about new advances in radiobiology.

• Chapter I: Introduction: Radiobiology and Radiobiologic Methods Course from the Center for Medical Countermeasures Against Radiation (CMCR) Consortium
• Chapter II: “Radiobiology Methods Web-Based Course” Prepared by the Center for Medical Countermeasures Against Radiation (CMCR) Consortium Coordinating Core, Joel S. Greenberger, M.D., Principal Investigator
• Chapter III: Overview: What is Radiobiology?
• Chapter IV: Practical Applications: Radiation Countermeasures, Radiation Safety Hospital and Home, Diagnostic and Radiation Therapy
• Chapter V: Radiation Chemistry: Origins of Life on Earth, SPEs, GCI, Gamma Rays
• Chapter VII: Sporadic High LET Radiation
• Chapter VIII:  Acute Radiation Effects: Total Body, Subtotal, Species Differences
• Chapter IX: Acute Radiation Effects: Organ Specific Organs Dose, and Species Differences:
  • Section A: CNS (Ionizing Irradiation Effects on the Brain, Spinal Cord, and Peripheral Nervous System)
  • Section B: Skin
  • Section C: Immune System
  • Section E: Oral/Oropharynx/Esophagus
  • Section F: Lung
  • Section G: Methods for Studying Radiation-Induced Acute Intestinal Damage and Regeneration in Mice
  • Section H: Rectum/Bladder/Prostate
  • Section I: Ionizing Irradiation Damage to Kidney
  • Section J: Large Animal Models
  • Section K: Effects of Total Body Irradiation on the Pregnant Female, Fetus and Placenta
  • Section L: Irradiation Effects on the Microenvironment
• Chapter X: Late Radiation Effects
  • Section A: Organ Failure, CNS, Cardiac, Aging – Senescence, Cancer and Leukemia
  • Section C: Lung Fibrosis
  • Section D: Cardiac
  • Section E: Aging/Senescence
  • Section G: Primate Late Effects Methods
• Chapter XI: Effect of Irradiation on Other Forms of Injury
  • Section A: Infection
  • Section B: Thermal Burn
  • Section C: Fracture
  • Section D: Overpressure Concussion
• Chapter XIV: Countermeasures Development Based on the Concept of an Evolution of “Radiation Diseases"
• Chapter XV: Methods for Study of Radiobiology: Overview
• Chapter XVI: Classic Radiobiology Methods
• Chapter XVII: New Radiobiology Methods
• Chapter XVIII: Specific Techniques in Radiobiology to Approach Specific Challenges
• Chapter XX: RNA-micro, siRNA, and Other RNA Moieties Involved in Radiation Biology
• Chapter XXI: Animal Models: ATm/ATr, Fanconi Pathway Proteins, and Scaffold for Nuclear DNA Repair
• Chapter XXII: Proteomics and Networks
• Chapter XXIII: Chemistry of Radiation Protectors
• Chapter XXIV: In Situ Correlations of Radiation Damage: From the Single Molecule to the Whole Animal
• Chapter XXV: Bone Marrow Transplantation – Animal Models
• Chapter XXVI: Bone Marrow Transplantation – Clinical and RITN
• Chapter XXVII: Critical Care Medicine and Management of Mass Radiation Casualties
• Chapter XXVIII: Dosimetry – Physical
• Chapter XXIX: Biodosimetry
• Chapter XXX: Biomarkers of Radiation Injury and Medical Countermeasures (MCM) Effects: Predicting Late Effects and Assessing MCM Efficiency
• Chapter XXXI: Product Development and Regulatory Considerations in Delivering Radiation-Nuclear Medical Countermeasures
• Chapter XXXII: The NIAID/CMCR Program Mission Relative to All the Chapters