Groshong Research Group

Our current lab is comprised of people from a variety of scientific backgrounds. Our interdisciplinary approach adds to the overarching goal to create science that has many different perspectives. Each of our current lab members specialize in their own project with a focus on Lyme disease spirochete, B. burgdorferi, and relapsing fever spirochete, B. hermsii.

With almost 30,000 cases reported in the United States and an estimated 300,000 cases annually, Lyme disease is the leading vector-borne disease in the United States. In contrast, from 1990 to 2011, there were only 504 confirmed cases of relapsing fever reported. The reduced incidence of relapsing fever has resulted in relapsing fever spirochetes being significantly understudied. However, given that B. burgdorferi and B. hermsii have ~70% identity between their chromosomes, they maintain vastly different enzootic cycles and disease states. Comparative studies between Lyme disease and relapsing fever are critical to understanding pathogen-vector-host biologies. As a lab, we have published papers on our findings and plan to continue our research in hopes of better understanding the morphological, ecological, and genetic characteristics that the Borrelia species play in the pathogen-vector-host interactions.

Ashley Groshong, Ph.D.

Principal Investigator and Chief, Bacterial Physiology and Metabolism Unit

Contact: For contact information, search the NIH Enterprise Directory.

Education:

Ph.D., University of Arkansas for Medical Sciences

B.S., B.A., University of Arkansas at Little Rock

Dr. Groshong received a B.S. in Biology and a B.A. in Chemistry and English at the University of Arkansas at Little Rock. She began studying Borrelia burgdorferi and its virulence determinants during her Ph.D. in Microbiology and Immunology at the University of Arkansas for Medical Sciences. She completed a postdoctoral fellowship at the University of Connecticut Health Center where she studied B. burgdorferi gene regulation throughout the enzootic cycle and continued on as an Instructor of Basic Science, where she began developing her studies on amino acid acquisition by the spirochete.

Learn more about Ashley Groshong, Ph.D.

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Samantha D. Crane, Ph.D.

Postdoctoral IRTA Fellow

Contact: For contact information, search the NIH Enterprise Directory.

Education:

B.S., Biological Sciences, 2017, Missouri University of Science and Technology, Rolla, MO

Ph.D., Interdisciplinary Biomedical Sciences (Microbiology and Immunology Track), 2021, University of Arkansas for Medical Sciences, Little Rock, AR

My research focuses on understanding the roles of Borrelia nutritional adaptations and requirements during the enzootic cycle of Lyme disease and relapsing fever spirochetes. I am interested in characterizing the pathogenesis of tick-borne relapsing fever and host responses to Borrelia burgdorferi and Borrelia hermsii.

Learn more about Samantha D. Crane, Ph.D.

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Kamryn T. Cregger, B.S.

Postbaccalaureate IRTA Fellow

Contact: For contact information, search the NIH Enterprise Directory.

Education:

A.S., 2020, Carroll Community College, Westminster, MD

B.S., Plant Science, Minor in Entomology and Plant Pathology, 2022, The University of Tennessee, Knoxville, TN

With a continuous passion for research and knowledge, I plan to spend two years as a postbaccalaureate research fellow in the Groshong laboratory. I will conduct research in the Laboratory of Bacteriology, focusing on the Borrelia species.

Learn more about Kamryn T. Cregger, B.S.

Headshot Kamryn T. Cregger

Clayton Jarrett, M.S.

Microbiologist/Technician

Contact: For contact information, search the NIH Enterprise Directory.

Education:

M.S., Microbiology, 2000, Montana State University, Bozeman, MT

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Arti Kataria, Ph.D.

Postdoctoral Visiting Fellow

Contact: For contact information, search the NIH Enterprise Directory.

Education:

B.S., Biotechnology, 2011, Dr. B.R Ambedkar University, Agra, UP, India

M.S., Biotechnology, 2013, Banaras Hindu University, Varanasi (BHU), UP, India

Ph.D., 2020, Indian Institute of Technology-Delhi (IIT-D), New Delhi, India

Languages Spoken: Hindi

Currently, I am investigating the role of amino-acid transporters in Borrelia burgdorferi.

Learn more about Arti Kataria, Ph.D.

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Adison G. Linder, B.S.

Postbaccalaureate IRTA Fellow

Contact: For contact information, search the NIH Enterprise Directory.

Education:

B.S., Molecular Biology, Spanish minor, 2024, University of Wyoming, Laramie, WY

Languages Spoken: Spanish

After spending my undergraduate career conducting research in the molecular genetics behind C. elegans cytoskeletal development and intracellular trafficking, I’m excited to bring my experience to the Groshong laboratory and explore the bacterial genetics of Borrelia. I plan to spend two years as a postbac studying spirochaete physiology and nutrient acquisition before applying to Ph.D. programs.

Learn more about Adison G. Linder, B.S.

Ashley A. Wilkins, Ph.D., M.S., R.Ph.T., C.Ph.T.

Postdoctoral IRTA Fellow

Contact: For contact information, search the NIH Enterprise Directory.

Education:

A.A.S., Pharmacy Technology, 2015, Austin Community College, Austin, TX
B.S., Biology (Microbiology Track), 2018, Texas A&M University-Corpus Christi, Corpus Christi, TX
M.S., Microbiology and Immunology, 2019, Tulane University School of Medicine, New Orleans, LA
Ph.D., Microbiology and Immunology, 2024, LSU Health Sciences Center-Shreveport, Shreveport, LA

My research focuses on understanding Borrelia burgdorferi's biology and pathogenicity. I am investigating its lipid requirements, characterizing a protein with D-Ala-D-Ala carboxypeptidase activity involved in peptidoglycan remodeling, and studying structural changes in Borrelia morphology using amino acid and peptide transport mutants. Additionally, I am exploring comparative spirochete...

Learn more about Ashley A. Wilkins, Ph.D., M.S., R.Ph.T., C.Ph.T.

Photo of Ashley A. Wilkins.

Former Research Group Members

  • Thomas Amabile, MPH, Pursuing M.D. at Eastern Virginia Medical School
  • Zachary Osterwind, Pursuing B.S. at Biola University
  • Amira-Nuriya McKinney, B.S.
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