Laboratory of Immunoregulation
Thomas C. Quinn, M.D., M.Sc.
Special Volunteer
Scientist Emeritus
Contact: For contact information, search the NIH Enterprise Directory.
Specialty(s): Infectious Disease, Internal Medicine
Highlight
Kidney Transplantation Between Donors and Recipients with HIV Is Safe
Kidney transplantation from deceased donors with HIV (HIV D+) to recipients with HIV (HIV R+) was safe and comparable to kidney transplantation from donors without HIV (HIV D-) in a multicenter observational study in the United States. The clinical outcomes observed were consistent with smaller pilot studies, but this National Institutes of Health (NIH)-funded clinical trial was the first statistically powered to demonstrate noninferiority, which means that an approach being studied is as good as standard clinical practice. The results were published today in the New England Journal of Medicine.
Major Areas of Research
- Definition of epidemiologic features of HIV-1 and HIV-2 infections in developing countries and the United States
- Assessment of biomedical interventions to control HIV, including circumcision, prevention of mother-to-child transmission, pre-exposure prophylaxis, and vaccine development
- Study of the serologic responses to SARS-CoV-2 and other coronaviruses to aid in the defining the epidemiologic features and clinical responses to COVID-19 in US and Africa
- Quantification of the latent HIV reservoir in virally suppressed Ugandan men and women with identification of immunologic predictors of the reservoir size
Program Description
HIV/AIDS is a global pandemic with 37 million individuals living with HIV infection worldwide. Approximately 2.1 million people become infected each year, and over 39 million people have already died as a result of HIV-related diseases. Although an estimated one million people are HIV infected in the U.S., the vast majority of HIV-infected individuals reside in developing countries. HIV infection continues to spread rapidly among heterosexuals and perinatally throughout Africa, Latin America, and Asia. Since the beginning of this project, the International HIV/STD Laboratory of the LIR has instituted international collaborations in 28 countries. The objectives of this lab are: 1) To define the unique epidemiologic, clinical, virologic, and immunologic features of HIV-1 infection and co-infections in developing countries; 2) To examine the viral kinetics and other biological and behavioral factors associated with HIV-1 transmission; 3) To characterize the molecular strains of HIV-1 by region for infectiousness, transmission, and immunologic response including the role of HIV superinfection; 4) To develop and evaluate novel interventions to prevent HIV transmission, including microbicides, circumcision and vaccines; 5) To examine the efficacy of antiretroviral drugs in preventing transmission and increasing survival in developing countries; 6) To examine the effects of HIV+ to HIV+ solid organ transplantation of patient health, HIV disease, and immunological make-up.
Awards
AOA Epidemiology Research Award; Charles C. Shepard Science Award; James H. Nakano Citation for Outstanding Scientific Publication; USPHS Outstanding Service Award; USPHS Meritorious Service Award; USPHS Distinguished Service Award; Thomas Parran Lifetime Achievement Award; Distinguished Leader in Global Health Award of CUGH.
Memberships
- American Association for the Advancement of Science
- Association of American Physicians
- American College of Physicians
- American Society for Microbiology
- American Society for Tropical Medicine and Hygiene
- American Federation for Clinical Research
- American Society for Clinical Investigation
- American Sexually Transmitted Diseases Association
- Infectious Disease Society of America
- IUSTI
- National Academy of Medicine, National Academies of Science
Editorial Boards
- AIDS Research and Human Retroviruses
- AIDS
- Infectious Diseases in Clinical Practice
- Journal of AIDS
- Journal of Clinical Investigation
- The Journal of Infectious Diseases
- Sexually Transmitted Diseases
Advisory/Review Boards
- Scientific Advisory Committee, HIV Vaccine Trials Network
- Scientific Advisory Committee, HIV Prevention Trials Network
- Scientific Steering Committee for Targeted Evaluations/Operations Research, Office of the U.S. Global AIDS Coordinator
- Chair, National Academy of Medicine Board of Global Health
- Member, IDSA Diagnostics Policy Task Force
- Advisor, MacArthur Fellows program
- Advisor, Global Health Interest Group of NIH
- Chair, Committee on Global Health, Infectious Diseases Society of America
Biography
Education
M.Sc., 1970, University of Notre Dame, IN
M.D., 1974, Northwestern University, Evanston, IL
Dr. Quinn obtained his M.D. from Northwestern University. He was a research associate in infectious diseases in the NIAID Laboratory of Parasitic Diseases and completed a fellowship in infectious diseases at the University of Washington. He returned to NIAID and later became chief of the Section on International HIV/STI Research. In 2006, he was appointed as associate director for International Research in the Division of Intramural Research. Since 1981, he has been assigned to the division of infectious diseases at Johns Hopkins University, where he became a professor of medicine in 1991, and in 2006 became director of the Center for Global Health. Dr. Quinn is a member of the National Academy of Medicine in the National Academies of Science and is a fellow of the American Association for the Advancement of Science and the Association of American Physicians.
Selected Publications
Hsieh YH, Rothman RE, Solomon SS, Anderson M, Stec M, Laeyendecker O, Lake IV, Fernandez RE, Dashler G, Mehta R, Kickler T, Kelen GD, Mehta SH, Cloherty GA, Quinn TC; Johns Hopkins COVID-19 Emergency Medicine Investigators. A Tale of 3 Pandemics: Severe Acute Respiratory Syndrome Coronavirus 2, Hepatitis C Virus, and Human Immunodeficiency Virus in an Urban Emergency Department in Baltimore, Maryland. Open Forum Infect Dis. 2022 Mar 16;9(5):ofac130.
Grabowski MK, Patel EU, Nakigozi G, Ssempijja V, Ssekubugu R, Ssekasanvu J, Ndyanabo A, Kigozi G, Nalugoda F, Gray RH, Kalibbala S, Serwadda DM, Laeyendecker O, Wawer MJ, Chang LW, Quinn TC, Kagaayi J, Tobian AAR, Reynolds SJ. Prevalence and Predictors of Persistent Human Immunodeficiency Virus Viremia and Viral Rebound After Universal Test and Treat: A Population-Based Study. J Infect Dis. 2021 Apr 8;223(7):1150-1160. doi: 10.1093/infdis/jiab021. PMID: 33471100; PMCID: PMC8030722.
Kared H, Redd AD, Bloch EM, Bonny TS, Sumatoh H, Kairi F, Carbajo D, Abel B, Newell EW, Bettinotti MP, Benner SE, Patel EU, Littlefield K, Laeyendecker O, Shoham S, Sullivan D, Casadevall A, Pekosz A, Nardin A, Fehlings M, Tobian AA, Quinn TC. SARS-CoV-2-specific CD8+ T cell responses in convalescent COVID-19 individuals. J Clin Invest. 2021 Mar 1;131(5):e145476.
Kagaayi J, Chang LW, Ssempijja V, Grabowski MK, Ssekubugu R, Nakigozi G, Kigozi G, Serwadda DM, Gray RH, Nalugoda F, Sewankambo NK, Nelson L, Mills LA, Kabatesi D, Alamo S, Kennedy CE, Tobian AAR, Santelli JS, Ekström AM, Nordenstedt H, Quinn TC, Wawer MJ, Reynolds SJ. Impact of combination HIV interventions on HIV incidence in hyperendemic fishing communities in Uganda: a prospective cohort study. Lancet HIV. 2019 Oct;6(10):e680-e687.
Grabowski MK, Serwadda DM, Gray RH, Nakigozi G, Kigozi G, Kagaayi J, Ssekubugu R, Nalugoda F, Lessler J, Lutalo T, Galiwango RM, Makumbi F, Kong X, Kabatesi D, Alamo ST, Wiersma S, Sewankambo NK, Tobian AAR, Laeyendecker O, Quinn TC, Reynolds SJ, Wawer MJ, Chang LW; Rakai Health Sciences Program. HIV Prevention Efforts and Incidence of HIV in Uganda. N Engl J Med. 2017 Nov 30;377(22):2154-2166.
Prodger JL, Lai J, Reynolds SJ, Keruly JC, Moore RD, Kasule J, Kityamuweesi T, Buule P, Serwadda D, Nason M, Capoferri AA, Porcella SF, Siliciano RF, Redd AD, Siliciano JD, Quinn TC. Reduced Frequency of Cells Latently Infected With Replication-Competent Human Immunodeficiency Virus-1 in Virally Suppressed Individuals Living in Rakai, Uganda. Clin Infect Dis. 2017 Oct 15;65(8):1308-1315.