Current AADCRC Projects

Center for International Blood and Marrow Transplantation Research (CIBMTR) Database

The CIBMTR database contains data on outcomes of hematopoietic (blood and bone marrow) cell transplant (HCT) procedures. The CIBMTR collaborates with government agencies, professional groups, international partners, and patient organizations via 15 active scientific/research working committees.

The CIBMTR database is co-funded by the National Heart, Lung, and Blood Institute, and the National Cancer Institute.

NIAID Cooperative Study Group for Autoimmune Disease Prevention (CSGADP)

CSGADP was established in 2001 as a collaborative network of investigators with a focus on halting the development of autoimmune disease prior to clinical onset by means other than global immunosuppression with an emphasis on Type 1 diabetes.

Main Areas of Focus

  • To engage in scientific discovery that significantly advances knowledge for the prevention and regulation of autoimmune disease
  • To identify common and disease-specific mechanisms of autoimmunity that can lead to novel pathways and methods to predict autoimmune disease and prevent its development
  • To connect markers of risk for autoimmune disease to alterations in immune function
  • To advance our understanding of genetic and environmental risk for autoimmune disease
  • To foster development of novel tools and approaches to the study of autoimmune disease risk, early pathogenesis, and onset of clinically apparent disease
  • To improve visibility and foster support for understanding early events and pathways toward prevention for systemic autoimmunity
Content Coordinator
Venera Barsaku
Content Manager
Adelina Bartels

Childhood Asthma in Urban Settings (CAUSE)

The Childhood Asthma in Urban Settings (CAUSE) network focuses on understanding how the environment, allergens, and genetics interact with the body’s immune system to cause asthma and aggravate its symptoms.

Main Areas of Focus

  • To understand the underlying mechanisms of candidate therapies
  • To develop and validate biomarkers to measure disease stage, progression, and therapeutic effect of candidate treatments
  • To assess how possible genetic and epigenetic (changes in gene expression or observable trait that are not caused by changes in DNA sequence) factors influence disease development, progression, and severity
  • To define the development and unique mechanisms associated with asthma onset and severity in children living in urban settings
  • To identify environmental factors associated with asthma in urban settings

See CAUSE clinical trials that are currently recruiting participants

Content Coordinator
Venera Barsaku
Content Manager
Adelina Bartels

Impact of CCR5 Blockade in HIV+ Kidney Transplant Recipients

The primary clinical goals of this multi-center clinical trial on HIV+ kidney transplant recipients are to evaluate the impact of CCR5 blockade (maraviroc, MVC) on renal function at week 52 post-transplant; as well as evaluate the overall safety and tolerability of CCR5 blockade in the HIV+ kidney transplant recipient.

Main Areas of Focus

The primary mechanistic goals of this trial are:

  • To define immunologic parameters associated with rejection in the HIV positive recipient (versus HIV+ non-rejectors)
  • To determine the impact of CCR5 blockade on the immunologic profiles in the HIV positive recipient
Content Coordinator
Venera Barsaku
Content Manager
Adelina Bartels

Immunobiology of Xenotransplantation Cooperative Research Program (IXCRP)

The Immunobiology of Xenotransplantation Cooperative Research Program (IXCRP) aims to develop preclinical porcine to nonhuman primate models of islet, kidney, heart, lung, or liver xenotransplantation.

Main Areas of Focus

  • To delineate the cellular and molecular mechanisms of xenograft rejection and the induction of tolerance
  • To develop effective strategies to improve xenograft survival
  • To characterize the physiological compatibility/limitations of xenografts
  • To develop novel and effective strategies for application of xenotransplantation in the clinic
Content Coordinator
Venera Barsaku
Content Manager
Adelina Bartels

Immune Development in Early Life (IDEaL) Program

The IDEaL Program supports research to expand our understanding of the establishment, development, and maintenance of immunity across childhood – from birth to 17 years of age. The program aims to provide foundational knowledge on the generation of durable immune responses, development of immune-mediated diseases, and strategies for improving vaccine efficacy in children.

Main Areas of Focus

  • Evaluation of age-dependent maturation of immune components in different populations and tissues (e.g., skin, gut, respiratory mucosa)
  • Longitudinal assessments following early life exposures (e.g., breastfeeding, environmental agents, infections, allergens)
  • Applications of innovative assays and technologies to evaluate immune cell populations and interactions in systems reflecting their physiological environments

Awarded Institutions

  • Columbia University Health Sciences
  • Ohio State University
  • University of California, San Francisco
  • University of Massachusetts Medical School, Worcester
  • University of Oxford
  • St. Jude Children’s Research Hospital
  • Boston Children’s Hospital
  • Johns Hopkins University
Content Coordinator
Venera Barsaku
Content Manager
Adelina Bartels
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Immune Tolerance Network (ITN)

Co-sponsored by NIAID and the Juvenile Diabetes Research Foundation International, the ITN is an international consortium of basic scientists and clinical investigators that performs clinical research to evaluate the safety and efficacy of methods that can induce the immune system to tolerate certain antigens for the treatment of immune-mediated disorders. Studies of immune tolerance in asthma and other allergic diseases are funded by the ITN.

Read more about this network: Immune Tolerance Network (ITN)

Main Areas of Focus

  • To accelerate the clinical development of immune tolerance therapies
  • To develop, fund, and conduct clinical trials in immune tolerance
  • To test the safety and efficacy of methods that can induce the immune system to tolerate certain antigens for the treatment of immune-mediated disorders
  • To conduct studies of immune tolerance in autoimmune disease, asthma and other allergic diseases, organ transplantation, and type 1 diabetes
Related Resources
Content Coordinator
Venera Barsaku
Content Manager
Adelina Bartels

Human Immunology Project Consortium (HIPC)

The Human Immunology Project Consortium (HIPC) is a network of researchers established to create a public resource that characterizes the diverse states of the human immune system. HIPC investigators use modern analytic tools to profile the immune system before and after infection, vaccination, or treatment with an adjuvant. The information gained from HIPC promises to improve the understanding of the human immune system and its regulation. It also will help scientists evaluate the safety and effectiveness of different vaccine formulations and administration techniques.

Read more about this network: Human Immunology Project Consortium (HIPC)

Main Areas of Focus

  • The study of well-characterized human cohorts using a variety of modern analytic tools, including:
    • Multiplex transcriptional, cytokine, and proteomic assays;
    • Multiparameter phenotyping of leukocyte subsets;
    • Assessment of leukocyte functional status; and
    • Multiple computational methods
  • To define profiles/signatures/fingerprints of steady-state and activated human immune system
  • To create centralized knowledge base and resources
  • To facilitate investigations of human immunity
  • To develop novel applications for human disease
Related Resources
Content Coordinator
Venera Barsaku
Content Manager
Adelina Bartels

HLA Region Genetics in Immune-Mediated Diseases Consortium

This purpose of this program is to understand how the human leukocyte antigen (HLA) gene region and killer immunoglobulin-like receptor gene family are associated with immune-mediated diseases.

Main Areas of Focus

  • To understand how the human leukocyte antigen (HLA) gene region and killer immunoglobulin-like receptor (KIR) gene family are associated with immune-mediated diseases
  • To support collaborative research focusing on the role of the HLA region and KIR genes in disease susceptibility and progression
Content Coordinator
Venera Barsaku
Content Manager
Adelina Bartels
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