The purpose of the protocol is to allow for patients, and relatives of patients, who may have the newly described autoimmune lymphoproliferative syndrome, to be evaluated at the NIH Clinical Center.

The objectives of this study are to evaluate improvement in laboratory measures of immune function; to evaluate any clinical benefit that accrues from the treatment; and to evaluate the safety of this treatment.

The goal of this study is to investigate if the seeding of lymph nodes by HIV early in the course of HIV infection and the persistent production of virus in lymph nodes throughout the course of infection are major factors in the pathogenesis of HIV in virtually all infected individuals.

The objective of this study is to collect cell samples from inside the noses of healthy people. These cells will be stored for use in future research on respiratory diseases.

This study will explore the cause of immunodeficiency in common variable immunodeficiency (CVI) and other related immunodeficiency syndromes-IgA deficiency, hyper IgM syndrome, thymoma and agammaglobulinemia, hypogammaglobulinemia associated with Epstein-Barr infection, and others to better focus on how to correct the underlying defect.

Researchers at the National Institutes of Health (NIH) are recruiting for an inpatient flu study to learn more about flu. If you are healthy and interested in helping us fight the flu, we need you for this research study!

This is a dose-finding and pathogenicity study following human challenge with a low pathogenicity avian influenza A H10N7. Participants will be inoculated with 1 dose of challenge virus during the study and then followed for a minimum of 9 weeks after inoculation. Progressively increasing doses will be used according to a specific plan until either the maximum dose is reached or at least 60% of participants develop mild to moderate influenza disease (MMID).

The purpose of this this study is to learn more about the immune system, how it responds to infections (like HIV) and to learn more about conditions that may decrease your immune system s ability to fight infections.

The objective of this study is to evaluate if the restoration of the vaginal microbiota to the infant at birth will restore the infant microbiome and decrease the risk of obesity and other immune-mediated diseases linked with Cesarean section (CS).

The goal of this study is to identify genetic mutations responsible for CAEBV. A secondary goal is to learn more about the natural history of CAEBV.

The purpose of this study is to collect blood and other specimens from people with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) to learn more about the illness.