The COVID-19: How SARS-CoV-2 binds to host cells module is part of the Pathogens in Augmented Reality (PathogenAR) mobile app. COVID-19 is a severe respiratory infection caused by the SARS-CoV-2 virus. In order to infect host cells, SARS-CoV-2 has a surface protein which can specifically bind to another surface protein on host cells. Disrupting this interaction is key to several vaccines and therapeutics currently in development. In this module, users learn about SARS-CoV-2 and this important first step to infection. Below is a list of resources to support this module.
Models in NIH 3D Print Exchange
- SARS-CoV-2 Open Spike (S Protein) with Ab Fragment
- SARS-CoV-2 Spike (S Protein) with ACE2
- SARS-CoV-2 Spike (S Protein) in closed conformation
- SARS-CoV-2 Spike (S Protein) in open conformation
- SARS-CoV-2 Virion
Read more about the NIH 3D Print Exchange
Protein Data Bank (PDB) Resources
NIAID Resources
References
- Walls A, Park Y, Tortorici M, Wall A, McGuire A, Veesler D. Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein. Cell. 2020;181(2):281-292.e6.
- Woo H, Park S, Choi Y, Park T, Tanveer M, Cao Y. et al. Developing a Fully Glycosylated Full-Length SARS-CoV-2 Spike Protein Model in a Viral Membrane. The Journal of Physical Chemistry B. 2020;124(33):7128-7137.
- Wrapp D, Wang N, Corbett KS, Goldsmith JA, Hsieh C-L, Abiona O, et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science. 2020;367(6483):1260–3.
- Yan R, Zhang Y, Li Y, Xia L, Guo Y, Zhou Q. Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science. 2020;367(6485):1444–8.
- Bar-On YM, Flamholz A, Phillips R, Milo R. SARS-CoV-2 (COVID-19) by the numbers. Elife [Internet]. 2020;9. Available from: http://dx.doi.org/10.7554/eLife.57309
- Barnes CO, West AP Jr, Huey-Tubman KE, Hoffmann MAG, Sharaf NG, Hoffman PR, et al. Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies. Cell. 2020;182(4):828-842.e16.